Features of menstrual function in women with morbid obesity

Abstract

The objective: a study the features of the course and onset of menstrual function in patients with morbid obesity (MO). Materials and methods. A survey of 97 patients of reproductive age with MO, who were included in the main group, and 60 healthy women, who were included in the control group, was performed. All women were comparable in age. The average age of the examined patients was 34.7±2.6 years. The body mass index of women in the main group was 38.8±4.2 kg/m2, the control group – 22.6±2.8 kg/m2.All patients gave informed consent to the processing of personal data. The obtained digital data were processed using licensed statistical programs Microsoft Office 2007 and Stata 12 by variational statistics methods. Results. The early menarche was observed in 35 (36.08%) patients of the main group versus 4 (6.67%) of the control group (p<0.05), late menarche – 38 (39.17%) and 7 (11.67%) women, respectively (p<0.05), menstrual dysfunction – 65 (67.0%) and 12 (20.0%; p<0.05), oligomenorrhea – 54 (56.67%) and 5 (8.33%; p<0.05), respectively, and hypermenorrhea – 38.14% of women in the main group. Often, patients with MO had menstrual irregularities in the form of shortened and heavy menstruations. In women with MO polycystic ovary syndrome – 21 (18.55%) patients, abnormal uterine bleeding – 37 (38.14%), endometrial hyperplasia – 18 (19.14%), uterine leiomyoma – 27 (27.83%), endometriosis – 22 (22.68%), infertility – 28 (28.86%) and benign breast diseases – 36 (37.11%) persons were diagnosed significantly more often compared to the healthy womenConclusions. In women with morbid obesity, a high frequency of disorders of the ovarian menstrual function was found, which may indicate the existence of a close relationship between the presence of obesity and the development of hormonal changes in the female reproductive system.