Features of kidney damage in endocrine diseases in children

Abstract

The purpose of the work is to determine the clinical and pathogenetic markers of secondary kidney damage in endocrine diseases in children to optimize the diagnosis of secondary nephropathies. Materials and methods. We examined 120 children with endocrinopathies aged 3 to 17 years: with secondary kidney damage in type 1 diabetes mellitus (25), exogenous constitutional obesity (20), autoimmune thyroiditis (15) and 60 children with endocrine diseases without kidney damage. All children underwent a clinical and paraclinical examination with an assessment of the endocrine and nephrological status: determination of the parameters of the lipid spectrum, glycemic profile, indicators of daily monitoring of blood pressure and the functional state of the kidneys. Results. Structural and functional parameters of the kidneys in patients with secondary nephropathies in endocrine diseases are characterized by: impaired echographic parameters of the kidneys and a decrease in intrarenal hemodynamics; increased blood pressure and hyperfiltration increased albuminuria/proteinuria in combination with dyslipidemia (increased low-density lipoprotein cholesterol, triacylglycerides, decreased high-density lipoprotein cholesterol), impaired carbohydrate metabolism (increased glycated haemoglobin levels, impaired glucose tolerance). Conclusion. The optimization of the diagnosis of secondary nephropathies in endocrine diseases in children is discussed based on the determination of a complex of clinical and pathogenetic factors that affect the formation of kidney pathology in children with endocrine diseases.