Features of hormonal homeostasis in women with climacteric syndrome associated with endometriosis

Abstract

The aim of the study was searching of endocrine homeostasis in patients with climacteric changes against the backdrop of endometriosis and establishing the correlative relationships between the severity of menopausal symptoms and hormonal changes.170 women with endometriosis were examined (of which 106 patients with endometriosis and climacteric manifestations – Group I, 64 with endometriosis without climacteric manifestations – Group II) and 153 women without endometriosis (of which 83 women with climacteric manifestations – Group III and 70 healthy women in the control Group IV). Women of all groups under study were divided into subgroups, depending on the age and phase of the menopause, and the concentration of sex steroid (estradiol, progesterone, testosterone) and gonadotropic (FSH and LH) hormones was investigated in the examined groups of patients prolactin, cortisol and cancer marker CA-125.As a result of the studies, installed the incidence of gonadotropic hormones (FSH, LH) and cortisol in the context of lowering the concentrations of sex steroid hormones compared with patients with climacteric syndrome (CS) without endometriosis was significantly higher in patients with CS in the context of endometriosis, which confirms the expressed asthenization in this contingent of women and early exhaustion they have an ovarian reserve. In this case, climacteric disorders develop in such women against the background of relative hyperestrogenemia, which indicates the involvement of other mechanisms for the development of CS in this category of women, in addition to estrogen deficiency, in particular hypercortisolemia.Therefore, summing up the above can be assumed that premenopause and climax, even physiological, are a stress factor for the woman’s body, which, along with the burdened comorbid state, causes significant stresses in the adaptive mechanisms and the launch of a stress-relieving system as a pathogenetic link in the development of moderate and severe forms of climacteric syndrome.