Features of global longitudinal deformation of the left ventricle in relation to coronary and carotid atherosclerosis in patients with coronary artery disease

Abstract

Background and Aims : Identify the relationship of the LV deformation properties with the presence of coronary and carotid atherosclerosis in patients with CAD.Methods: 94 patients with CAD of class II-IV aged 40 to 70 years were studied by the general clinical and laboratory blood tests, Holter -ECG monitoring, TTE, 2D-Echo with speckle tracking (STE), ultrasound of carotid artery lesions and coronary angiography (CAG). The SYNTAX score was calculated retrospectively in accordance with the SYNTAX evaluation algorithm. All patients were divided into 2 groups: group 1 included patients with a low syntax index (0-22); group 2 included patients with an average syntax index (23-32). A more objective quantitative assessment of the contractile function of the LV myocardium was obtained by assessing the global longitudinal deformation (GLS) and the strain rate (SR).Results: A comparative analysis showed that in group 2, GLS and SR indicators were significantly lower than in group 1 (P=0.0001 and P=0.0133, respectively). GLS was significantly correlated with LVL (r=-0.309; P<0.005), with the degree of atherosclerotic damage to the coronary arteries (r=0.925; P<0.005) and the number of atherosclerotic plaques in the carotid arteries (r=0.245; P<0.05). SR was also correlated with LVL (r=-0.281; P<0.005), coronary artery disease (r=0.767; P<0.0005) and the number of atherosclerotic plaques of the carotid arteries (r=0.233; P<0.05).Conclusions: The results obtained indicate the diagnostic value of STE with the determination of GLS and SR in a comprehensive assessment of severity of coronary and carotid atherosclerosis within group of patients with CAD. Background and Aims : Identify the relationship of the LV deformation properties with the presence of coronary and carotid atherosclerosis in patients with CAD. Methods: 94 patients with CAD of class II-IV aged 40 to 70 years were studied by the general clinical and laboratory blood tests, Holter -ECG monitoring, TTE, 2D-Echo with speckle tracking (STE), ultrasound of carotid artery lesions and coronary angiography (CAG). The SYNTAX score was calculated retrospectively in accordance with the SYNTAX evaluation algorithm. All patients were divided into 2 groups: group 1 included patients with a low syntax index (0-22); group 2 included patients with an average syntax index (23-32). A more objective quantitative assessment of the contractile function of the LV myocardium was obtained by assessing the global longitudinal deformation (GLS) and the strain rate (SR). Results: A comparative analysis showed that in group 2, GLS and SR indicators were significantly lower than in group 1 (P=0.0001 and P=0.0133, respectively). GLS was significantly correlated with LVL (r=-0.309; P<0.005), with the degree of atherosclerotic damage to the coronary arteries (r=0.925; P<0.005) and the number of atherosclerotic plaques in the carotid arteries (r=0.245; P<0.05). SR was also correlated with LVL (r=-0.281; P<0.005), coronary artery disease (r=0.767; P<0.0005) and the number of atherosclerotic plaques of the carotid arteries (r=0.233; P<0.05). Conclusions: The results obtained indicate the diagnostic value of STE with the determination of GLS and SR in a comprehensive assessment of severity of coronary and carotid atherosclerosis within group of patients with CAD.