Abstract
The purpose of the study is to identify the peculiarities of the functioning of the vascular-thrombocyte linkage of hemostasis in the experimental periodontitis.Material and methods. Experimental manipulations were performed on white nonlinear male rats weighing 260.0 ± 30.0 g, in which experimental periodontitis was induced. Determination of total, free and bound oxyproline in urine was carried out using the method of P. N. Sharaev. Analysis of the aggregation curve included the definition of such indicators: 1) the degree of aggregation — the maximum% of light transmission of the plasma; 2) time to achieve maximum aggregation rate — time to achieve maximum% light transmission; 3) the rate of aggregation, which was calculated 30 seconds after the beginning of platelet aggregation. Results. Studying the functional activity of platelets in rats with experimental periodontitis revealed signs of changes in the functions of the platelet linkage hemostasis. In periodontitis in connective tissue periodontium and thrombocyte hemostasis, metabolic disorders of the connective tissue were revealed, which is the level of oxyproline in the urine of animals.Conclusions. In the experimental periodontitis, clear changes in the functional activity of the platelets were detected. In parallel with the decrease in the functional activity of platelets in the periodontitis, the level of urine in all three oxyproline fractions is reduced. The obtained results testify to the commonality of processes occurring in the blood and connective tissue and associated with metabolic disorders in it, decrease in the synthesis and collagen collapse.
Highlights
Мета дослідження — виявити особливості функціонування судинно-тромбоцитарної ланки гемостазу при експериментальному пародонтиті
Experimental manipulations were performed on white nonlinear male rats weighing 260.0 ± 30.0 g, in which experimental periodontitis was induced
Analysis of the aggregation curve included the definition of such indicators: 1) the degree of aggregation — the maximum% of light transmission of the plasma; 2) time to achieve maximum aggregation rate — time to achieve maximum% light transmission; 3) the rate of aggregation, which was calculated 30 seconds after the beginning of platelet aggregation
Summary
Мета дослідження — виявити особливості функціонування судинно-тромбоцитарної ланки гемостазу при експериментальному пародонтиті. In periodontitis in connective tissue periodontium and thrombocyte hemostasis, metabolic disorders of the connective tissue were revealed, which is the level of oxyproline in the urine of animals. In parallel with the decrease in the functional activity of platelets in the periodontitis, the level of urine in all three oxyproline fractions is reduced. Вивчення функціональної активності тромбоцитів у щурів з експериментальним пародонтитом виявило ознаки початку змін функцій тромбоцитарної ланки гемостазу. При концентрації індуктора агрегації 2,5 мкмоль/л ступінь агрегації тромбоцитів, час досягнення максимальної швидкості агрегації та швидкість агрегації у тварин практично не відрізнялись від параметрів контрольної групи тварин Таблиця 1 Показники агрегації тромбоцитів у щурів з експериментальним пародонтитом при концентрації АДФ 2,5 мкмоль/л (X±SX, n=20)
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