FEATURES OF FOLLICULOGENESIS, OOGENESIS AND EMBRYOGENESIS OF WOMEN IN ART CYCLES ON THE BACKGROUND PATHOLOGY OF THE THYROID GLAND

Abstract

Introduction. In recent years, the relationship becomes actuality problem of violations of reproductive and thyroid glands (thyroid). On the one hand, this is due to the fact that the prevalence of infertility in marriage is 13-15% and in spite of the advancements in the field of human reproductive medicine, there is no downward trend. On the other hand, thyroid diseases occupy first place in the structure of endocrine pathology among women of reproductive age. Purpose - improving the efficiency restore reproductive function in women with infertility in thyroid pathology background. Results and discussion. The features of folliculogenesis, oogenesis and embryogenesis of women in art cycles on the background of thyroid disease. The detection rate of low level AMH in patients with pathology of the thyroid was 2.5 times above, than in women without thyroid pathology. In women young and middle age with disorders of the thyroid was dominated by low and medium levels of AMH, while the high level of AMH was only every third women aged 20-27 years (36,4%) and every 6 patients in the age 28-35 years, indicating a decrease in ovarian reserve in women with thyroid pathology. Conclusions. The studies indicate a reduction in the basic parameters ovarian reserve in patients with thyroid disorders compared with a group of women without thyroid pathology, namely, the significant reduction in average concentrations of AMH and FSH levels rise in average decreased ovarian volume (<5 cm 3) was diagnosed in 3 7 times more frequent in the group of patients with thyroid disorders. The normal ovarian volume (5 -10 cm 3) in the first group experienced 1.5 times less than in the second group. The average number of antral follicles in the ovaries of patients with thyroid disorders was significantly lower than in the control group. Thus, women with thyroid disorders in assisted reproduction cycles found significantly lower rates folliculogenesis and embryogenesis compared with women without thyroid disease.