Abstract
BACKGROUND: The development of osteoporosis in males is associated with a complex interaction of various factors, including: deficiency of sex hormones, heredity, physical activity, nicotine use, etc. In young men with Hodgkin's lymphoma, the development of the osteoporotic process is very multifactorial due to the influence of tumor cells, pathogenetic therapy, as well as a secondary decrease in androgens on the composition of bone tissue and a decrease in BMD. AIMS: To determine the parameters of bone mineral density in young men with Hodgkin's lymphoma and to assess the risks of osteoporosis associated with pathogenetic therapy of the disease. MATERIALS AND METHODS: The study included 26 men, of whom 14 were diagnosed with Hodgkin's lymphoma, and the control group included 12 healthy males. All patients underwent a two-adsorption X-ray scan of bone tissue in the lumbar spine, as well as the femur. The following parameters were identified and studied: MPC, Z-criterion, T-criterion for all participants in both study groups. RESULTS: The analysis of bone mineral density in patients with Hodgkin's lymphoma showed a significant decrease in the parameter in two measurement areas: the lumbar spine and the proximal femur. Significantly more often in men with Hodgkin's lymphoma, a decrease in the Z-criterion to osteopenia/osteoporosis was noted in the lumbar spine. A decrease in the T-criterion in patients with Hodgkin's lymphoma to osteopenia/osteoporosis was noted in the proximal and femoral neck. CONCLUSIONS: Young men with Hodgkin's lymphoma who have received pathogenetic therapy, including cytostatic drugs and glucocorticosteroids, are at high risk of developing the osteoporotic process and its complications. The decrease in densitometric parameters (MPC, Z-criterion, T-criterion) in patients with Hodgkin's lymphoma to osteopenia/osteoporosis, noted in the proximal part and femoral neck, indicates a high risk of fractures of this localization and requires the development of a strategy for their prevention.
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