Year-end Sale % OFF 
Abstract
According to American Cancer Society, there estimated to have one million new colorectal cancer cases worldwide each year, and half of them die from clinical complications and metastasis. The dominant metastasis site for patient with colon cancer is liver. In this report, a 77-year-old male presented with occult blood in stool, weight loss and abnormal liver function tests. Previous medical history of the patient included upper GI bleeding due to duodenum ulcer and alcohol drinking for many years. Abdominal CT scan indicated obstructive sigmoid colon lesion with multiple liver metastasis. Colonoscopy revealed a nearly obstructed lesion in sigmoid colon. Palliative colostomy was performed and sigmoid mass was resected. Pathology examination demonstrated that tumor was originated from mucosa and invades through submucosa, muscular propria and pericolonic fat. Tumor cells showed moderately differentiated, high nuclear grade with calcification, necrosis and vascular invasion. The TNM staging was used and the American Joint Committee on Cancer (AJCC) tumor staging was 2a (pT3N0Mx). This case presented typical pathology features of colon cancer relate to liver metastasis. Life time alcohol consumption is one of the risk factors for colon cancer liver metastasis. Besides behavior and life style, genetics and epigenetic factors play important roles in liver metastasis in colorectal carcinoma patients. Colon cancer is an insidious disease and almost half of the cases in the United States are diagnosed at late stages. Metastasis to the liver is leading cause of death in patients with colon cancer. Epigenetic biomarkers, such as circulating factors in serum, are developed for noninvasive molecular diagnosis of colon cancer at early stage as well as colon cancer with liver metastasis. Genetics and epigenetics studies provided molecular adjuvant therapy regimens for metastasis and evaluation for prognosis.
Highlights
According to American Cancer Society, they estimated to have one million new colorectal cancer cases worldwide each year
Liver is dominant dissemination site and hepatic metastases develop in approximately half of colorectal cancer cases
Investigate morphology and mechanisms of colon cancer cell dissemination to liver are critical for early diagnosis, prompt treatment and prevention
Summary
According to American Cancer Society, they estimated to have one million new colorectal cancer cases worldwide each year. The dominant metastasis site for patient with colon cancer is liver. A case of colon cancer with liver metastasis is presented. Patient had history of daily drinking which provided added evidence that alcohol is a risk factor for colon cancer development and liver metastasis. Patients who have history of alcohol consumption should have careful examination of liver for distant cancer dissemination. Understanding the mechanisms of colon cancer liver dissemination will provide principles for the diagnosis, treatment and prevention of advanced colon cancer. Abdominal Computed Tomography (CT) scan revealed obstructive sigmoid colon lesion with liver metastasis (Figure 1A,1B). His previous history was insignificant except for upper gastrointestinal bleeding due to duodenum ulcer. The TNM staging was used and the American Joint Committee on Cancer (AJCC) tumor staging was 2a (pT3N0Mx)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
