Abstract
Varicocele is the most common cause of spermatogenesis disorders. Pathogenesis of pathospermia in combination with varicocele has not been fully studied. Many authors believe that the disruption of germ cell formation is associated with DNA fragmentation and oxidative stress. We present an example of clinical observation of a patient with varicocele combined with pathospermia. This article demonstrates that when treating infertile patients with varicocele, it is necessary to expand the diagnostic search to determine the percentage of DNA fragmentation of the sperm with the aim of identifying the reasons for violations of spermatogenesis. Pathogenetically justified antioxidant therapy after varicocelectomy improves the quality of the ejaculate and reduces the level of DNA fragmentation. Conclusions: surgical treatment of varicocele (varicocelectomy) is indicated for infertile men to improve sperm fertility.
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