Abstract
The basal c-AMP content and the rate of spontaneous lipolysis in isolated adipocytes of spontaneously hypertensive rats were found not to differ from those in normotensive Wistar rats. The response of both these parameters to inhibition of phosphodiesterase activity by caffeine or to adrenaline after caffeine were not different in spontaneously hypertensive rats from normotensive rats. However, significant differences between hypertensive and normotensive rats were found after adrenalectomy: Adipocytes of both the intact and adrenalectomized hypertensive rats possess greater sensitivity to ACTH than adipocytes of the respective normotensive groups. Comparison of the sensitivity of the adipose tissue of hypertensive and normotensive rats to ACTH at various calcium concentrations indicates that the differences obtained are determined by disturbances in the compartmentalization of calcium in the adipocytes of the hypertensive animals. This conclusion is supported by the study of45Ca redistribution in adipose tissue of adrenalectomized normotensive and hypertensive animals.
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