Feature and Presentations of Suspected Harboring Prostate Cancer Patients: A Study in a Tertiary Care Hospital in Bangladesh

Abstract

Background: Prostate cancer is the most common cancer in males of increasing age. It is the second leading causes of cancer mortality among the men throughout the world. There are many etiological factors are associated with increased the risk of prostatic carcinoma including male hormone and its active metabolites, genetic predisposition, environmental factors, racial difference, food habits etc. A pathway with an imaging test may decide which men with an elevated PSA and/or suspected digital rectal examination will undergo biopsy. Aim of the study: The aim of this study was to assess the feature and presentations of suspected harboring prostate cancer patients. Methods: This was cross- sectional analytical study conducted in the Department of Urology, Sir Salimullah Medical College & Mitford Hospital, Dhaka, Bangladesh during the period from July 2018 to June 2020. A total of 50 male patients had undergone mpMRI of prostate and TRUS biopsy and histopathology were enrolled in this study as study population. All data were processed, analyzed and disseminated by using MS Excel and SPSS version 22.0. Results: In this study, the mean age of the participants was found as 69.14±8.48 years. The most frequent complaint of them was frequency of urination in 84%. The mean S. PSA was found as 41.78 ± 28.097 ng/ml. More than one third (38%) of patients were found to have volume of prostate 41-60 cc and the mean volume was found as 57.26 ± 19.026 cc. The mean PI-RADS score of our respondent was 3.32±1.34 ranging from 1 to 5. As mpMRI of prostate, majority (36%) patients had PI-RADS: 4. As per the histopathological diagnosis, it was found that, 34% of study patients were diagnosed as benign nodular hyperplasia. On the other hand, remaining 66% were diagnosed as carcinoma of prostate. In this study, the range of Gleason scores of the participants was found as 6-10. Conclusion: PI-RADS score, mpMRI and S. PSA assessment may be considered as some prominent evaluation methods .....