Feasibility Study on Rapid Analysis of Doxycycline Hydrochloride Aqueous Solution by Terahertz Time-Domain Spectroscopy

Abstract

Abstract. Antibiotics have been extensively applied in the treatment of infections in food-producing animals. However, the residues of these agents create a potential risk to human health. Among the methods available for rapid detection of antibiotics, terahertz time-domain spectroscopy (THz-TDS) has emerged as a technique with unique advantages over other methods. In this study, we demonstrate that rapid analysis of doxycycline hydrochloride (DCH) aqueous solutions could be achieved with THz-TDS through transmission, attenuated total reflection (ATR), and reflection with minimum detectable concentrations of 5000, 10, and 80 mg L-1, respectively, indicating that the ATR and reflection methods are superior to the transmission method for low-concentration aqueous solutions. This study is an effort to promote the development of rapid analysis of antibiotic residues in an aqueous matrix using THz spectroscopy. Keywords: Attenuated total reflection, Doxycycline hydrochloride solution, Reflection, Terahertz, Transmission.