Abstract
Abstract Bacterial keratitis is a widespread disease in which bacteria have infected the cornea. This can lead to blindness and should be treated immediately after diagnosis. However, antibiotics do not reach pathogens inside the cornea. Therefore, it is investigated whether UVB irradiation might be a feasible therapy that reaches and inactivates bacteria even deep inside the cornea. Thus, the cornea transmission of porcine eyes was measured to reveal a high UVB penetration. As Escherichia coli (E. coli) is one of the relevant pathogens, E. coli suspensions were irradiated by a 311 nm UVB lamp, to explore the antimicrobial impact of the UVB radiation. Finally, as a worst-case scenario, it was investigated whether E. coli behind the cornea was also inactivated. A cornea transmission of 36.4 ± 5.9 % was observed at 311 nm and an irradiation dosage of 1.9 J/cm2 was found for a three log reduction of E. coli in suspension. The reduction of E. coli by 311 nm irradiation even behind the cornea could be confirmed. Therefore, by this approach, it should be possible to reach bacteria even deep inside the cornea by means of UVB irradiation as a fast keratitis therapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
