Feasibility of Phototherapy as a Community-Based Solution for Vitamin D Deficiency

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Abstract Objectives 1. Determine acceptability and feasibility of a phototherapy kiosk designed as a self-care intervention for low vitamin D; 2. Demonstrate that narrow spectrum ultraviolet (UV) B delivered by the kiosk is equivalent to recommended daily D3 supplementation to raise or maintain serum 25-hydroxyvitamin (OH)D levels at or above 30 ng/mL; and 3. Examine the relationship of demographic variables, including age, gender, body mass index, physical activity, ethnicity, skin type, season, and sun exposure to serum 25(OH)D levels in both treatment arms. Methods Participants were randomized to either the phototherapy kiosk (PK) for a treatment every other week or 600 IU D3 oral supplement (OS) daily, for 10 weeks. PK exposure was based on response to previous treatment and Fitzpatrick Skin Type category; subjects wore undergarments only and eye protection for treatments of 2–6 minutes duration. OS group received a one-time prescription of 70 capsules, dispensed by a research pharmacist. Primary outcome was serum 25(OH)D level. Results Final sample 88 adults; OS group n = 45 and PK group n = 43. Demographics: median age 35 years, mostly female (66%), no difference observed between groups for age, race/ethnicity, or marital status. No difference seen in skin type, birth location, sun exposure, or use of sunscreen. OS group had higher BMI and %body fat. Baseline 25(OH)D level were similar, P = 0.25. At 12 weeks median OS 25(OH)D 25.5 ng/mL and PK 30 ng/mL; P = .01. At 16 weeks, OS group 25(OH)D level 21 ng/mL and PK 27 ng/mL; P = .04. Adherence: OS 92% vs PK 100%. There were no reportable adverse events. Conclusions Use of PK every other week achieved higher serum levels of 25(OH)D than usual care vitamin D3 600 IU/day for 10 weeks, although both groups returned to baseline levels 30 days post-treatment. At a time when self-care measures are highly valued for health promotion, programmed UVB delivered via PK in the community appears to be a safe, efficacious alternative to oral D3 supplementation but requires recurring use. Results from this study suggest a need for early intervention in preventable health conditions impacting Warfighter performance and readiness, particularly pre-deployment when optimizing long-term wellness for duty in austere environments. Funding Sources Benesol, Inc.