Abstract
ObjectivesA novel approach in the evaluation of peripheral arterial disease is the photo-optical oxygen tension measurement (pTCpO2). This modality is suggested to be more practical in use in comparison to standard electro-chemical oxygen tension measurement. Hence, pTCpO2 might be of added value to evaluate revascularization of the lower extremities peri-procedural. We conducted a preliminary feasibility study to analyze the potential of pTCpO2 during revascularization. MethodsTen patients scheduled for revascularization of the lower extremities were enrolled. pTCpO2 values of the affected lower extremity were measured pre-operatively, during revascularization and after revascularization. Results were compared to the pre- and postoperative ankle-brachial index (ABI) and to perioperative angiography. Primary endpoint was the feasibility of perioperative pTCpO2 measurement. Secondary endpoints were concordance between pTCpO2, ABI, angiography and clinical outcome. ResultsTwo out of twelve measurements were unsuccessful. Eight out of ten patients experienced significant clinical improvement and pTCpO2 increase. Two patients that did not experience clinical improvement corresponded with no changes in intraoperative angiography and without increase in ABI or pTCpO2. A significant and strong correlation was found between prior and after revascularization ABI and pTCpO2 measurements (r = 0.82 P = 0.04). ConclusionsPhoto-optical transcutaneous oxygen tension measurement may serve as an intraoperative tool to evaluate the success of revascularization. pTCpO2 could be an alternative for the ABI to determine the success of lower extremity revascularization.
Highlights
A novel photo-optical approach of TCpO2 measurement, has been introduced.[1]
Clinical success was compared with delta ankle-brachial index (ABI) (T1-T0), delta pTCpO2 (T2-T0) and perioperative angiographic success, defined as an increase of flow distal of the lesion, reviewed by two vascular surgeons blinded to ABI and pTCpO2 results
One patient experienced no clinical improvement with delta ABI -0.11, delta pTCpO2 -31.0 mm Hg and no angiographic improvement
Summary
A novel photo-optical approach of TCpO2 measurement (pTCpO2), has been introduced.[1] This photo-optical technique defines the partial oxygen pressure based on a light-emitting-diode and photodiode. The underlying mechanism of this technique is explained elsewhere.[2] pTCpO2 has been proposed as more precise and more practical in use as the electro-chemical TCpO2 measurement.[3–5]. Current pTCpO2 measurement might be an interesting alternative tool to assess the success of revascularization perioperative. PTCpO2 measurement can be conducted with small handheld devices. This technique is practical in use and probes are applied on the lower extremities during revascularization
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
