Feasibility of LDF Measurements of Optic Nerve Head Blood Flow in Children with Cerebral Malaria

Abstract

The pathogenesis of cerebral malaria (CM), a significant cause of death in the tropics, is still not understood. Cerebral blood flow measurements would be important but are difficult under the conditions prevailing in CM clinics in the tropics. With the goal of using optic nerve head (ONH) blood flow ( F onh) instead of cerebral blood flow to help outcome prediction, we have tested the feasibility of performing F onh measurements in comatose CM children, using a portable ocular laser Doppler flowmeter (LDF). Measurements were performed in one eye of each of 13 children (2.7 ± 1.1 years) during a period of about 8 min. The Vel onh (the relative blood velocity), Vol onh (the relative blood volume), and F onh values were determined for each child from three to five measurements of 2 to 20 s. Average Vel onh, Vol onh, and F onh values were 0.49 ± 0.08 kHz, 2.4 ± 1.06 arbitrary units (a.u.), and 89 ± 16.8 a.u., respectively. The average coefficients of variation of the flow parameters based on all segments in each child were 13 ± 9% (range 1–29%) for Vel onh, 27 ± 13% (range 3–65%) for Vol onh, and 23 ± 12% (range 5–42%) for F onh. This study demonstrates the feasibility of LDF measurements in CM children. The large range of these coefficients of variations could be due to the presence of fluctuations of ONH blood flow on a short time scale in these neurologically unstable children.