Abstract
In diseases with poor local control, functional imaging for radiotherapy (RT) guidance may better define tumor extent and identify regions with high tumor burdens for dose escalation. In diseases already having excellent control, dose de-escalation and volume reduction may be feasible with imaging that reflects residual tumor activities after induction chemotherapy or in mid-RT. Due to reported high sensitivity of FDG PET in predicting tumor viability, we focused on childhood rhabdomyosarcoma and characterized the heterogeneity of uptake within tumors.
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