Feasibility and Workflow Efficiency in MRI-Based HDR Brachytherapy for Cervical Cancer at a Community-Based Practice

Abstract

Image-guided brachytherapy (IGBT) has seen widespread use in high-volume centers around the country in the last ten years. GEC-ESTRO recommendations stipulate that the dose be prescribed to the high-risk clinical target volume, which includes the residual tumor present at the time of brachytherapy. This practice has resulted in lesser normal tissue toxicity and improved local control. We introduced MRI volumetric planning at our center three years ago to confer this advantage to our patients. Based on a practice pattern survey by the American brachytherapy society in 2014, IGBT with MRI-based planning was grossly underutilized due to challenges associated with the work stream and availability of MRI. The combined mean procedure time for MR imaging and planning reported at a high-volume brachytherapy center was 63.2 minutes. Our study aimed to identify the time required for MRI-based IGBT for the first HDR fraction for cervical cancer patients at our institution. We aim to understand how we differ from a typical high-volume center and how we may improve our efficiency and workflow. Between 2020 and 2023, 14 patients were treated with HDR brachytherapy for a diagnosis of cervical cancer. Of these individuals, 7 patients were treated with MRI-guided IGBT during the first HDR fraction. The following time intervals were recorded: 1. Time from applicator insertion to completion of MRI imaging 2. Time from completion of MRI imaging to start of CT simulation 3. Time from start of CT simulation to completion of treatment delivery Materials and methods: Between 2020 and 2023, 14 patients were treated with HDR brachytherapy for a diagnosis of cervical cancer. Of these individuals, 7 patients were treated with MRI-guided IGBT during the First HDR fraction. The following time intervals were recorded: 1. Time from applicator insertion to completion of MRI imaging 2. Time from completion of MRI imaging to start of CT simulation 3. Time from start of CT simulation to completion of treatment delivery. The mean total procedure time was 582 minutes (Range 494- 665). The mean time and ranges for each phase were as follows. The mean time from the implant insertion to MRI completion was 157.7 minutes (Range 70-307), and the time from MRI completion to the start of CT simulation was 114.7 minutes (Range 17-173), and the time from the start of CT simulation to the treatment delivery was 310 minutes (Range 251-476). Our study demonstrates that MRI-based HDR brachytherapy with a skilled multidisciplinary team in a small community-based practice with an MRI imaging facility is a feasible approach similar to a high-volume center but differs in the total treatment time. Considering high treatment time in the community-based practice, the department is taking a team approach to improve efficiency. This includes establishing a dedicated brachytherapy suite closer to the MRI imaging and incorporating artificial intelligence to assist planning.