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Abstract
Surgical management of pancreatic cancer depends on tumor resectability and staging. Lymph node (LN) metastases represent an important decision-making factor when it comes to surgical treatment. To evaluate a new in vivo, endoscopic confocal microscopy (CM) system not requiring fluorescence markers, for detection and staging of pancreatic cancer in rats. A confocal system consisting of a confocal scanning laser operating in reflection mode and a dedicated rigid Hopkins rod-lens endoscope were used for in vivo imaging in a rat model of pancreatic ductal adenocarcinoma. A double-blind study compared CM to standard histology in (1) the detection of tumors in rat bearing cancer (n=11) and controls (n=6), and (2) in the detection of local nodal involvement at 3 and 6weeks after tumor induction. CM detected all pancreatic tumors with 100% sensitivity and specificity and identified 15 metastatic LNs with an average adenocarcinoma nodule diameter of 2.3mm (range from 1 to 4.2mm) out of the 66 examined. CM demonstrated a sensitivity of 87.5% and a specificity of 98% in LN detection. The Spearman's rank correlation/rho calculator was of 0.87. CM demonstrated a negative predictive value of 96.1% and a positive predictive value of 93.3% in the detection of metastatic LNs. Interpretation of confocal images has a high concurrence rate with histopathology examination for primary tumor and lymphatic involvement detection making it a promising technique for in vivo real-time detection and staging of pancreatic cancer. Larger studies are warranted to confirm these preliminary results.
Published Version
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