Feasibility and impact of an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a tertiary care university medical center.

Johannes P Borde,Hartmut Bertz,Klaus Kaier,Winfried V Kern,Martin Hug,Werner Vach,Annette Geibel-Zehender,Michaela Steib-Bauert,Katja De With,Hansjörg Busch

doi:10.1186/1471-2334-14-201

Johannes P Borde, Hartmut Bertz + Show 8 more

Open Access

https://doi.org/10.1186/1471-2334-14-201

Copy DOI

Abstract

BackgroundRestricted use of third-generation cephalosporins and fluoroquinolones has been linked to a reduced incidence of hospital-acquired infections with multidrug-resistant bacteria. We implemented an intensified antibiotic stewardship (ABS) programme in the medical service of a university hospital center aiming at a reduction by at least 30% in the use of these two drug classes.MethodsThe ABS programme was focused on the 300-bed medical service. Prescription of third-generation cephalosporins was discouraged, whereas the use of penicillins was encouraged. Monthly drug use density was measured in WHO-ATC defined and locally recommended daily doses (DDD and RDD) per 100 patient days, to evaluate trends before (01/2008 to 10/2011) and after starting the intervention (1/2012 to 3/2013). The effect was analysed using interrupted time-series analysis with six non-intervention departments as controls.ResultsFollowing initiation of the ABS intervention, overall antibiotic use in the medical service declined (p < 0.001). There was a significant intervention-related decrease in the use of cephalosporins and fluoroquinolones (p < 0.001) outperforming the decreasing baseline trend. Trend changes observed in some of the control departments were smaller, and the difference between trend changes in the medical service and those in control departments were highly significant for overall use and cephalosporin use reductions (p < 0.001) as well as for the increasing use of penicillins (p < 0.001). Mean use density levels (in RDD per 100 patient days) dropped for cephalosporins from 16.3 to 10.3 (−37%) and for fluoroquinolones from 17.7 to 10.1 (−43%), respectively. During the same period, the use of penicillins increased (15.4 to 18.2; 18%). The changes in expenditures for antibiotics in the medical service compared to control services minus programme costs indicated initial net cost savings likely to be associated with the programme.ConclusionAn intensified ABS programme targeting cephalosporin und fluoroquinolone use in the setting of a large academic hospital is feasible and effective. The intervention may serve as a model for other services and hospitals with a similar structure and baseline situation.

Highlights

Restricted use of third-generation cephalosporins and fluoroquinolones has been linked to a reduced incidence of hospital-acquired infections with multidrug-resistant bacteria
Recent observations show that reduced prescribing of particular other antibacterial drug classes, notably third-generation cephalosporins [5,6] and fluoroquinolones (FQ) [6,7], may reduce the incidence of hospital-acquired C. difficile [8,9,10,11], methicillin-resistant Staphylococcus aureus (MRSA) [12,13,14] and gram-negative bacteria producing extended-spectrum betalactamase (ESBL) [15,16]
Following the initiation of the intensified antibiotic stewardship (ABS) programme, the overall antibiotic use density in the medical service declined by 14-20%

Summary

Introduction

Restricted use of third-generation cephalosporins and fluoroquinolones has been linked to a reduced incidence of hospital-acquired infections with multidrug-resistant bacteria. Recent observations show that reduced prescribing of particular other antibacterial drug classes, notably third-generation cephalosporins [5,6] and fluoroquinolones (FQ) [6,7], may reduce the incidence of hospital-acquired C. difficile [8,9,10,11], methicillin-resistant Staphylococcus aureus (MRSA) [12,13,14] and gram-negative bacteria producing extended-spectrum betalactamase (ESBL) [15,16]. Reducing the antibacterial drug use density in tertiary care centers may be challenging [17] These centers serve as referral hospitals for patients with difficult to treat conditions and enhanced risk for complications including healthcare-associated infection that may require aggressive treatment. The tendency in many acute care hospitals is an increase in antimicrobial drug use density rather than a decrease [19,20] which in part is explained by decreasing lengths of stay and in part by an ever increasing number of patients with more complex diseases

Methods

Results

Discussion

Conclusion