Fe3O4@l-Proline/Pd nanocomposite for one-pot tandem catalytic synthesis of (±)-warfarin from benzyl alcohol: synergistic action of organocatalyst and transition metal catalyst

Abstract

One-pot synthesis of (±)-warfarin from scratch! The reported catalytic nanocomposite can carry out 3-way catalysis, namely, oxidation, aldol condensation and Michael addition, in a tandem fashion in PEG-400 and water as 'green' reaction media.