Fe3O4@ZnS@Glycine nanoparticle as a novel microwave stimulus controlled drug release system

Abstract

The stimuli-responsive controlled drug delivery system is highly desirable for an efficient cancer treatment approach. Herein, we have successfully developed a novel multifunctional microwave stimulus controlled anticancer drug release system based on magnetic Fe3O4@ZnS@Glycine nanoparticles. Fe3O4 core has a high magnetization saturation value for drug targeting under foreign magnetic fields. ZnS shells can efficiently convert microwave energy into thermal energy for microwave-triggered drug release. The glycine-modified layer of nanoparticles provides active group (–NH2) for the loading of drug molecules by hydrogen bond. The in vitro studies have clearly demonstrated the feasibility and advantage of the novel nanocarriers for remote-controlled drug release systems. We combined the advantages of ZnS nanoparticles with those of Fe3O4 and glycine to create a new drug delivery system, which is capable of carrying drug molecules and triggered release of the drug by microwave treatment.