Fe3O4/ZnO/multi‐walled carbon nanotubes magnetic nanocomposites promoted five components synthesis of new imidazole derivatives

Abstract

In this research, we have synthesized imidazole derivatives in high yields using the five component reactions of N‐methylimidazole, dialkyl acetylenedicarboxylates or propiolates, α‐haloketones, triphenyphophine, and ammonium acetate in water at room temperature in the presence of nanocatalyst. The Fe3O4/ZnO/multi‐walled carbon nanotubes (MWCNTs) magnetic nanocomposites were utilized well as an organometallic catalyst in these reactions. This catalyst was synthesized utilizing the ionic liquid [OMIM]Br as a stabilizer and soft template. Also, this catalyst is high performance and improvement in the yield of the imidazoles and displayed significant reusability. In the synthesized compounds because of having imidazole core, we study the ability of antioxidant of some of them by diphenyl‐picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. In addition, for investigation of antimicrobial activity of some imidazoles, the disk diffusion experiments are utilized on Gram‐positive and Gram‐negative bacteria. The outcomes of this experiment exhibited that these generated compounds could avoid from growth of bacteria. Short time of reaction, high yields of product, and easy separation of catalyst and products are some advantages of this process.