Abstract
Currently, photodynamic therapy (PDT) has been greatly restricted by the tumor hypoxia. To overcome this problem, here, we designed a novel nanoplatform, Fe3O4@MIL-100(Fe)-UCNPs (abbreviated as FMU), in which UCNPs were acted as energy transducers to transfer NIR-UV/vis light to the heterojunction photosensitizer Fe3O4@MIL-100(Fe) (abbreviated as FM), producing cytotoxic hydroxyl radicals (OH) with a high tumor cell oxidation capability independent of tumor oxygen. In particular, the recombination of electrons and holes has been markedly inhibited due to the formation of heterojunctions in the interfaces between MIL-100(Fe) and Fe3O4 nanoparticles, thus greatly enhancing the capability for OH production. Meanwhile, the Fe3+/Fe2+ ions were used to provide the photochemotherapy (PCT) effect based on the photo-Fenton reaction, thereby achieving combined PDT and PCT synergistic therapy. The outstanding antitumor efficiency was verified by in vivo and in vitro assays, and it was shown that the therapeutic process can be monitored by computed tomography (CT) and upconversion luminescence (UCL) imaging, suggesting that the resultant nanoplatform has potential for use in imaging-guided cancer therapy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
