Fe3O4@chitosan-tannic acid bionanocomposite as a novel nanocatalyst for the synthesis of pyranopyrazoles

Maryam Kamalzare,Mohammad Reza Ahghari,Ali Maleki,Mohammad Bayat

doi:10.1038/s41598-021-99121-2

Maryam Kamalzare, Mohammad Reza Ahghari + Show 2 more

Open Access

https://doi.org/10.1038/s41598-021-99121-2

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Abstract

Recently magnetic nanocatalyst has attracted considerable attention because of its unique properties, including high performance, easy separation from the reaction mixture, and recyclability. In this study, a novel magnetic bionanocomposite was synthesized with chitosan and tannic acid as a natural material. The synthesized bionanocatalyst was characterized by essential analysis. Fe3O4@chitosan-tannic acid as a heterogeneous nanocatalyst was successfully applied to synthesize pyranopyrazole and its derivatives by a one-pot four-component reaction of malononitrile, ethyl acetoacetate, hydrazine hydrate, and various aromatic aldehyde. At the end of the reaction, the nanocatalyst was separated from the reaction mixture and was reused several times with no significant decrease in its catalytic performance. Simple purification of products, the ability for recovering and reusing the nanocatalyst, eco-friendliness, high yields of pure products, mild reaction conditions, short reaction time, non-toxicity, economically affordable are some of the advantages of using the fabricated nanocatalyst in the synthesis of pyranopyrazole.

Highlights

Magnetic nanocatalyst has attracted considerable attention because of its unique properties, including high performance, easy separation from the reaction mixture, and recyclability
Another efficient and green heterogeneous catalyst for the synthesis of pyranopyrazole and its derivatives is R uIII@CMC/Fe3O4; high performance, short time, mild reaction condition, easy workup, reusability, simple preparation of the catalyst with an external magnet, and green catalytic procedure are the main advantages of this p rocedure[6]
A new heterogeneous magnetic nanocatalyst synthesized by chitosan, tannic acid and the structural features of the bionanocomposite were investigated by FT-IR, Field emission electron microscopy (FE-SEM), VSM, transmission electron microscopy (TEM), X-ray diffraction (XRD), EDX, and thermogravimetric analysis (TGA) analysis

Summary

Introduction

Magnetic nanocatalyst has attracted considerable attention because of its unique properties, including high performance, easy separation from the reaction mixture, and recyclability. Another efficient and green heterogeneous catalyst for the synthesis of pyranopyrazole and its derivatives is R uIII@CMC/Fe3O4; high performance, short time, mild reaction condition, easy workup, reusability, simple preparation of the catalyst with an external magnet, and green catalytic procedure are the main advantages of this p rocedure[6].

Results

Conclusion