Fe(III), Co(II) & Cu(II) Complexes of N,N’-Bis[2-salicylideneamino]ethane-1,2-diamine: Preparation, characterisation and in vitro antibacterial activity

Abstract

Salicylaldehyde derived hexadentate Schiff base N,N’-Bis[2-salicylideneamino]ethane-1,2-diamine (TTS) and its complexes with Fe(III), Co(II) and Cu(II) metal ions have been prepared and characterised by elemental analysis, UV-visible, IR, 1 H NMR, EPR spectral analysis, mass spectrometry and XRD method. In vitro antibacterial activity of the Schiff base and its metal complexes against Gram positive bacterial strains Staphylococus aureus , Bacillus subtilis and Gram negative bacterial strains Enterobacter , Escherichia coli has revealed that the metal complexes are more active to the bacterial strains as compared to that of the Schiff base. The Co-TTS has the highest antibacterial activity against Escherichia coli , while the Fe-TTS complex is highly active against Enterobacter , Staphylococcus aureus and Bacillus subtilis.