Abstract
Two new mixed ligand metal complexes of Fe(III) and Co(II) chloride hexahydrate salts were prepared using standard methods. Ampicillin trihydrate and oxytetracycline hydrochloride antibiotics were used as ligands. Chemical analysis including conductivity measurements, molecular weight determination and spectroscopic studies were used to propose the geometry and mode of binding of the ligands to metal ions. Both ligands were proposed to coordinate to metal ions in ratio 1:1:1 in the complexes. Each of the ligands acted as terdentate ligand. Inhibition properties as well as toxicity effect of administration of the metal complexes at the dose of 3.33 mg/kg body weight thrice daily for 5 days on the alkaline phosphatase (ALP) activities on rat kidney, liver and serum were evaluated. The inhibitory properties of the complexes were found to be significantly different (P 0.05) in ALP from liver and kidney sera. The results indicated that more potent compounds with better physical properties and enhanced antimicrobial activities upon complexation have been prepared. Key words: Metal complexes, complexation, antibiotics, antimicrobial properties, alkaline phosphatase.
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