Abstract
Tissue Engineering (TE) is a multidisciplinary field where material science, cellular and molecular biology meet to develop practical solutions for restoring damaged tissue. Whilst intensive research has been carried out towards the development of suitabl e polymers for the scaffold application, end product considerations such as behaviour and constraints are often omitted hereby limiting their possible high impact in the fields of skin, cardiovascular and bone tissue regeneration. In this work, we report the use of the Finite Element Method (FEM) as an essential tool for material selection and prosthesis design. Applied to cardiovascular TE and, more particularly, to Heart Valve (HV) replacement therapy, an FEM model was developed to study the mechanics (regurgitation, maximum stress and strains and valve opening, etc.) of a bioprosthetic tri-leaflet HV. Through the present approach, the results were twofold: material selection and validation for both the stent and leaflet components of an aortic valve prosthetic device.
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