Abstract
Objective We aim to investigate the correlation between FCGR2A mRNA level and prognosis of head and neck squamous cancer (HNSC) in public databases. In addition, we investigated the correlation between FCGR2A expression and clinicopathological characteristics and tumor-infiltrating immune cells in HNSC patients. Methods FCGR2A mRNA expression in multiple cancers was analyzed based on Gene Expression Profiling Interactive Analysis. A protein-protein interaction network was obtained based on the STRING database. The 10 proteins most closely related to FCGR2A (i.e., CD3G, PLCG2, LAT, LYN, SYK, FCGR3A, PIK3R1, HCK, ITGAM, and ITGB2) were screened, followed by establishing the protein-protein interaction network. The correlation between FCGR2A expression and immunocytes was investigated, together with the effects of FCGR2A on the metastasis, recurrence, and survival of HNSC. Results FCGR2A expression in several carcinoma tissues was significantly higher than that of adjacent tissues. Significant differences were noticed in the HNSC samples and the adjacent tissue samples except the seven samples of grade 4. There were statistical differences between the FCGR2A expression in tissues of grade 1, grade 2, and grade 3 (P < 0.05). In the tissues of grade 4, the expression of FCGR2A was the lowest. The FCGR2A protein was a type of II-a receptor in γFc of the low-affinity immunoglobulin, which could bind with the Fc region of the immunoglobulin γ. There was a correlation between the FCGR2A gene and the distal HNSC metastasis. FCGR2A gene expression was correlated with the survival and prognosis. The GSE65858 dataset was selected for the validation. The FCGR2A expression was significantly correlated with total survival (P = 0.0107) and progression-free survival (P = 0.0362). Conclusions Our findings shed light on the importance of FCGR2A in HNSC and illustrated a potential relationship between FCGR2A and tumor-immune interactions.
Highlights
Head and neck squamous cancer (HNSC), one of the most common types of human malignancy, shows an annual incidence of more than 780,000 cases worldwide [1,2,3]
According to the Human Protein Atlas website, the FCGR2A gene was expressed in various tissues
This demonstrated a relationship with therapeutic sensitivity, which may serve as a potential biomarker for treatment and prognosis of HNSC [16, 18]
Summary
Head and neck squamous cancer (HNSC), one of the most common types of human malignancy, shows an annual incidence of more than 780,000 cases worldwide [1,2,3]. The FCGR2A gene, responsible for encoding the FcγRIIa protein, is localized at 1q23 [5] consisting of 10 exons and 9 introns. It is a member of the immunoglobulin Fc receptor (FCGR) gene on the surface of cells involved in immune responses. FcγRIIa is divided into two subtypes including FcγRIIa and FcγRIIb, which are classified as IgG receptors with low to moderate affinity. It is mainly involved in binding with IgG, and is expressed in the neutrophils, monocytes, macrophages, dendritic cells
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
