Abstract
MACROMOLECULAR exchange across the foeto–maternal interface in the pregnant mammal is in some species confined to the placenta, whereas in others such as the rabbit, rat and mouse, the yolk sac is also involved1. Whatever the route, it is well established that whereas most proteins are broken down during their passage into the foetus, a small proportion of certain immunoglobulins is transferred to the foetal circulation intact. This has important implications not only for the transmission of passive immunity but also for the access of potentially deleterious maternal antibody directed against foetal antigens.
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