Abstract
Levels of c -myc mRNA have been assayed in mouse B cells cultured for 8 hr with Fab' 2 anti-Ig or IgG anti-Ig. Fab' 2 anti-Ig induces DNA synthesis in B cells, whereas the whole molecule inhibits anti-Ig-induced DNA synthesis by crosslinking the B cell Fcγ R to mIg. Both the Fab' 2 fragment and the IgG anti-Ig induce an increase in c -myc mRNA by 1 hr. Thereafter, levels in cells stimulated with submitogenic doses of Fab' 2 anti-Ig or any dose of IgG anti-Ig returned to background, while levels in cultures containing a mitogenic dose of Fab' 2 anti-Ig remained elevated.
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