Abstract
In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma.
Highlights
Human pro-oncogene FBI-1 is a master transcriptional regulator that belongs to the POK protein family [1]
To determine if endogenous FBI-1 may be involved in ETS-1 transactivation, the Small interfering RNA (siRNA) targeted to FBI-1 was used to diminish FBI-1 protein level
We provide evidence for the novel role of FBI-1 in colorectal carcinoma cells
Summary
Human pro-oncogene FBI-1 is a master transcriptional regulator that belongs to the POK protein family [1]. It has been known by several names such as LRF (leukemia/lymphomarelated factor) [2] or Pokemon (POK erythroid myeloid ontogenic factor) [3]. FBI-1, characterized by the BTB/POZ domain, plays an important role in the regulation of development and progression of various cancers, like breast cancer, hepatocellular carcinoma and leukemia [4]. FBI-1 would repress p53 signaling activity through regulating Hdm, Mdm, and p19ARF, p21 and Rb expression [1,6,7,8]. The results showed that FBI-1would interact with ETS-1, which plays certain roles in cancerous cells proliferation, migration and invasion. It is valuable to declare the interaction between FBI-1 and ETS-1
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