Favorable effect after single treatment session of 755-nm-picosecond laser with a diffractive optic lens on facial wrinkles and pore size in Asians.

Abstract

Laser therapy has become one of the mainstay treatments for improvingsigns of aging including wrinkles, large pores, and skin pigmentation. However, in patients with pigmented skin, an increase in complicationsincludingpost-inflammatory hyperpigmentation (PIH) has been noted. The purpose ofthisstudy is to investigate not only the safety profile of 755-nmpicosecond laser withdiffractive lens array (DLA)at approximately 2250pulseson the facein people with darker skin, but also to evaluateitsefficacyin treating wrinkles and pore sizesafter one treatment sessionamong different age groups. This single-center, retrospective study enrolled patients between age 22 and 65 with both facial wrinkles and enlarged pore sizes. A total of 46 patients (7male, 39 female, mean age 43) with Fitzpatrick skin types III and IV were enrolled. Two independent data-blinded dermatologists assessed and scored the improvements of patients' wrinkles and pore sizes using photographs. After onetreatmentsession, statistically significant improvements were observed in lateral canthal wrinkles (p<0.001) and facial wrinkles (p=0.014).In addition, greater percentage of the patients from the aged group (50-65years) showed clinically significant improvement as compared with the younger group. For patients withtype III and IV skin,one session of DLApicosecond lasertreatment at around 2250 pulses to the face is safe and effective for clinically meaningful improvement of the wrinkles and pore sizes, especially forthe patients from 50- to 65-years of age.