Abstract
Introduction: Adipose tissue has recently been characterized as an endocrine organ which secretes proinflammatory adipocytokines including leptin, TNF-α, IL-6, and IL-1β. Visceral steatosis results in a local inflammatory mileu resulting in organ dysfunction with nonalcoholic steatohepatitis being a well established example of this phenomenon. Previous data from our lab have shown that obese mice with increased pancreatic fat have elevated inflammatory adipocytokines. In addition, these mice with increased fat in their pancreas develop more severe pancreatitis when challenged with cerulein.
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