Abstract
A study was conducted to determine the extent to which choline metabolism is involved in the production of fatty livers in rats fed diets high (40%) in fat and high (0.1%) in niacin. Fatty livers produced in animals fed excess niacin and non-protective levels of choline could be reversed by the addition of choline to the diet. Data from determination of N1-methylnicotinamide excretion, serum alkaline phosphatase activity, and liver lipids suggested that the appearance of fatty livers in animals fed excess niacin resulted from an induced choline deficiency.
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