Fatty acids in cord blood plasma, the relation to soluble CD23 and subsequent atopy

Abstract

Atopy is suggested to be linked to the balance between levels of n-6 and n-3 series of long chain polyunsaturated fatty acids (PUFAs) in the diet. In a nested case-control study, levels of fatty acids, IgE and soluble low affinity IgE receptor (sCD23) were measured in cord blood in 35 children who subsequently developed allergic sensitisation and atopic dermatitis before the age of 3, and similarly in 35 matched children without a history of atopy. We found a tendency to lower levels of the n-3 PUFAs eicosapentaenoic acid (EPA) and alpha-linolenic acid (ALA) in the cord blood plasma of atopics compared to non-atopics. Levels of sCD23 were negatively correlated to levels of n-3 series of PUFAs and n-9 eicosenoic acid, and levels of n-9 eicosenoic acid was negatively correlated to levels of IgE. There was no association between the levels of sCD23 and n-6 PUFAs. Lower levels of n-3 PUFAs in cord blood may be associated with the development of atopy in children. A possible mechanism may be through the regulation of CD23, thereby influencing IgE synthesis.