Abstract
Observations on fatty acid metabolism in the denervated muscle of frog contrast both in respect to fat accumulation and fatty acid metabolism with the data obtained for dystrophic muscle elsewhere. Dystrophy leads to fat accumulation in the skeletal muscle. Denervation-atrophy in the gastrocnemius muscle of frog for one month resulted in the depletion of fat composition and fatty acid synthesis. Unlike dystrophic muscle the denervated muscle does not undergo reduction in mitochondrial protein, and shows an increase in palmitate and pyruvate oxidation. Although these changes are diametrically opposite, both the disorders viz. denervationatrophy and dystrophy, are due to changes in mitochondrial activity.
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