Abstract
The fatty acid composition of both mitochondrial and microsomal lipids of rat liver following acute ethanol intoxication was studied. Six hours after ethanol administration a decrease in arachidonic and docosahexaenoic acids of both total lipids and phospholipids of liver mitochondria was observed. At the same time an increase in each fatty acid content of microsomal phospholipids occured. No significant changes in the fatty acid composition of mitochondrial lipids were observed 1.5 hours after ethanol intoxication. The U.V. absorption of mitochondrial lipids does not show the presence of conjugated dienes. Besides other hypotheses, the possibility of an ethanol-induced lipoperoxidation process, occuring in the mitochondrial membranes, is discussed.
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