Abstract
AbstractThe fatty acid composition of ceramides has been determined in kidney and cerebellum of a patient with Farber's disease, which is characterized by ceramidase deficiency. Farber cerebellum and kidney contained a five‐ and ten‐fold excess, respectively, of free ceramides. The nonhydroxy fatty acid patterns of the ceramides from Farber kidney and cerebellum showed considerable similarities to those from control tissues, whereas large amounts of ceramides containing hydroxy fatty acids are found in Farber's disease tissues.
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