Abstract
The effect of undernutrition on the fatty acid profiles of cerebrosides and phospholipids in the developing rat brain has been investigated. Undernutrition was imposed post-natally in pups by the method of large litter size and feeding a protein-deficient diet during the post-weaning period. The results showed that lignoceric (24:0) and nervonic (24:1) acids of cerebrosides, which are marker fatty acids of myelin, were significantly lower in 50-day-old undernourished rats than in well-nourished controls. Among the polyunsaturated fatty acids of phospholipids the contribution of arachidonic acid (20:4) to the total fatty acids was lower in 10- and 21-day-old as well as 50-day-old rats. Altered fatty acid pattern of lipid classes might be the result of impaired myelination of brain due to nutritional stress.
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