Abstract
A diet deficient in n–3 fatty acids dramatically reduces docosahexaenoic acid (4.8-fold) and 20:5n–3 content in murine total peroxisomal phospholipids, and conversely increases 22:5n–6 (17.1-fold) and also, to a lesser extent, 20:4n–6. This was also found in purified phosphatidylethanolamine and phosphatidylcholine. After changing the non-deficient diet (containing α-linolenic acid, ALA) to a deficient one (deficient in ALA), it took a very long time for docosahexaenoic acid concentration in peroxisomes to decline (>5 months). In contrast, after changing the deficient to a non-deficient diet, time to complete recovery was more rapid (3 weeks). Changes in 20:5n–3, 22:6n–3 and 20:4n–6 were generally stabilized within 2–4 weeks. Dietary n–3 fatty acids control the fatty acid composition of peroxisomal membranes, and thus possibly affect some of their functions.
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