Abstract
An enzyme histochemical study was carried out on fat‐storing cells, which are distributed in the space of Disse of mammalian liver. The livers used for study consisted of human autopsy materials demonstrating either acute or chronic circulatory disturbance. Fat‐storing cells contain abundant glycogen, and demonstrate a marked γ‐glutamyl transpeptidase activity and a weak lactate dehydrogenase activity. It is highly probable that an active glyconeo‐genesis rather than glycogenolysis is being carried out in these cells. In acute circulatory disturbance, an elevated alkaline phosphatase activity is found in the wall of sinusoids. This phenomenon is a manifestation of activated capillary endothelial cells participating in the regeneration of liver parenchyma. On the other hand, in chronic congestive liver, elevated γ‐glutamyl transpeptidase activity in fat‐storing cells is concerned in the proliferation of fibers in the wall of sinusoids, and elevated pressure in sinusoids is considered to be the main factor in its increased activation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.