Fatores de Risco para Malignidade e Mortalidade Intra-Hospitalar em Meningiomas

Abstract

Introduction: Meningiomas are tumors derived from arachnoidal cap cells, being benign, in most of the cases. Research is needed for a better understanding of the prognostic factors that may correlate with survival and tumoral malignancy in patients with meningiomas. Objective: To study the clinical characteristics of risk for hospital mortality and malignancy in intracranial meningiomas. Methods: Gathering of clinical, radiological and histopathological data from hospital records of patients with meningiomas treated by the Neurosurgery Service of the Hospital Ophir Loyola between January 1, 2002 and December 31, 2012. Results: The factors related to atypical and malignant lesions were tumor size and male gender. Laterality of injury, trauma, and tumor site were not identified as risk factors. The total mortality was 16.84%. Factors such as age at diagnosis and tumor size were found directly proportional to the risk of this outcome. Finally, tumor location and other factors investigated did not affect the mortality rate. Conclusion: Tumor size affects both the risk of malignancy and hospitalar mortality. Age and male gender are additional factors of poor prognosis.