Abstract
: This paper highlights some key concepts related to fatigue and the seminal role of the 1981 Ciba Foundation Symposia "Human Muscle Fatigue: Physiological Mechanisms" chaired by R.H.T. Edwards in consolidating key ideas that have moved the study of fatigue forward since that time. I also consider these concepts in their historical context via the pioneering work of the Italian physiologist and social activist Angelo Mosso in the late 1800s. Finally, fatigue as a multidimensional concept with implications beyond muscle physiology is considered.
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