Fatigue, Somnolence and Depression Persist After Six Month In Recovered Individual After The Acute Covid-19 (P14-4.003)

Abstract

<h3>Objective:</h3> To assess depression/anxiety symptoms, fatigue and daytime sleepiness in individuals previously affected by the COVID-19 infection. <h3>Background:</h3> Neuropsychiatric symptoms may persist after the COVID-19 infection. <h3>Design/Methods:</h3> We included 1183 cases of post-Covid infection (79% women; median age 41 [12–77]) who answered an interview of our online survey (median interval 191 days [50–503] after the infection). We used the Hamilton Anxiety and Depression Scale to evaluate anxiety (HADS-A) and depression symptoms (HADS-D), the Chalder Fatigue Scale to measure the fatigue severity and the Epworth Sleepiness Scale to assess daytime sleepiness. Individuals also answered the PHQ-9 (Patient Health Questionnaire-9). Patients were separated according to the treatment type (home [1046, median 41 years], ward [87, median 45.5 years] or ICU [50, median 48.5 years]). We performed Mann-Whitney tests to compare continuous variables among groups and Spearman tests for correlations. <h3>Results:</h3> Anxiety symptoms were more severe in ICU patients (median score 12 [0–19]) compared to the home group (median score 9 [0–21]; p=0.012). Similarly, the severity of physical fatigue was higher in the patients treated in ICU (median score 16 [2–21]) compared to home treatment (median score 13 [0–21]; p=0.004). However, the depression severity (p=0.1), PHQ-9 scores (p=0.06), mental fatigue (p=0.06) and daytime sleepiness scores (p=0.6) were similar among the three groups. Overall, there were positive correlations between sleepiness and both mental (r=0.33, p&lt;0.001) and physical fatigue (r=0.44, p&lt;0.001). The PHQ-9 scores positively correlated with sleepiness (r=0.36, p&lt;0.001), mental fatigue (r=0.63, p&lt;0.001) and physical fatigue (r=0.73, p&lt;0.001). Interestingly, these correlations were present for the three groups, even after splitting according to treatment. <h3>Conclusions:</h3> We confirmed persistent symptoms of fatigue, daytime sleepiness, anxiety and depression in a large group of recovered individuals after six months from the acute infection. Surprisingly, patients with mild infection presented equivalent intensity of mental fatigue, somnolence and depression, compared to those who required hospitalization. <b>Disclosure:</b> Prof. João has received research support from FAPESP. Lucas Silva has nothing to disclose. Mr. Carvalho has nothing to disclose. Dr. Karmann Aventurato has received research support from Coordenadoria de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES). Miss Costa has nothing to disclose. Mariana Brito has nothing to disclose. Mateus Nogueira has nothing to disclose. Dr. Alvim has nothing to disclose. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB Pharma. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB Biopharma. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for United Medical – Brazil. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Zodiac Pharma . Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eurofarma – Brazil . Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Epilepsia. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Frontiers in Neurology - Epilepsy. The institution of Dr. Cendes has received research support from São Paulo Research Foundation - FAPESP. The institution of Dr. Cendes has received research support from Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brazil . The institution of Dr. Cendes has received research support from NIH. Clarissa Yasuda has nothing to disclose.