Abstract

The instruments that measure the impact of fatigue on physical, cognitive and psychosocial aspects has yet to be validated in Brazilian population with Parkinson's disease (PD). The aim of this study was to cross-culturally adapt and assess the psychometric properties of the Brazilian version of the Modified Fatigue Impact Scale (MFIS-PD/BR). Ninety PD individuals were recruited. The adaptation of the MFIS-PD was performed by translation and back translation methodology. Psychometric analysis was applied in order to perform the administration of the socio-clinical questionnaire, Mini-Mental State Examination (MMSE), Unified Parkinson's Disease Rating Scale (UPDRS Part I-IV), Hoehn-Yahr disability scale (HY), hospital anxiety and depression scale (HADS), Geriatric Depression Scale (GDS), fatigue severity scale (FSS), Parkinson Fatigue Scale (PFS-16), and MFIS-PD/BR with retest of the MFIS-PD/BR after 7 days. The adaptation phase kept the same items of original MFIS-PD. The Cronbach's alpha for the MFIS-PD/BR was 0.878 when all responses items were scored. The test-retest intraclass correlation coefficients was above 0.80 (p<0.01) for the MFIS-PD/BR score, which was moderately correlated with the HADS, GDS, MDS-UPDRS score total and non-motor experiences of daily living, FSS and PFS-16. It was revealed the MFIS-PD/BR>29 points as cut-off point to indicate fatigued subjects with accuracy of 0.835 (p<0.001). The MFIS-PD/BR is valid and reproducible to use in assessing the fatigue symptom in Brazilian PD subjects.

Highlights

  • Fatigue is one of the most common and bothersome nonmotor symptoms in Parkinson’s disease (PD)[1,2,3] with prevalence estimates ranging from 15 to 78%4,5

  • The translation and back-translation versions were similar to the Modified Fatigue Impact Scale (MFIS)-PD original[9]

  • No subject demonstrated any problem in understanding the MFIS-PD/BR confirming the content and face validity

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Summary

Introduction

Fatigue is one of the most common and bothersome nonmotor symptoms in Parkinson’s disease (PD)[1,2,3] with prevalence estimates ranging from 15 to 78%4,5. Common definitions include a sense of exhaustion or a subjective lack of physical and/or mental energy perceived by the individual, which interferes with usual or desired activity[4,8]. It is a complex and highly subjective symptom with many uncertainties regarding its pathophysiology. The instruments that measure the impact of fatigue on physical, cognitive and psychosocial aspects has yet to be validated in Brazilian population with Parkinson’s disease (PD). Conclusions: The MFIS‐PD/BR is valid and reproducible to use in assessing the fatigue symptom in Brazilian PD subjects

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