Abstract
Celiac disease may present with a range of different symptoms, including abdominal problems in a broader sense, iron deficiency and “constant tiredness”. All of these symptoms should consequently lead the clinicians to consider celiac disease as a potential etiopathogenetic cause. Although the pathophysiology of celiac disease is well documented, the actual mechanisms for disease presentation(s) are less well understood. We here address the topic of fatigue in celiac disease. A systematic literature search identified 298 papers of which five met the criteria for full evaluation. None of the reviewed papers were of high quality and had several methodological weaknesses. We conclude that there is an unmet need to study the contributing factors and management of fatigue in celiac disease.
Highlights
Celiac disease is by definition an inflammatory disorder in the small intestine that is driven by dietary gluten from wheat, rye and barley [1]
Due to the limited number of publications on fatigue in coeliac disease, no time limit was set for the papers
Two studies [11,12] investigated potential socio-demographic and clinical factors associated with fatigue, finding that there is no association between fatigue and factors such as gender, age, or GI symptoms in celiac disease
Summary
Celiac disease is by definition an inflammatory disorder in the small intestine that is driven by dietary gluten from wheat, rye and barley [1]. In a recent review by Leffler et al [3] this is well described, including anaemia, musculoskeletal, skin, neurological and organ-specific manifestations. Some of these manifestations are caused by the intestinal disorder, others may be caused by systemic inflammation and/or genetic overlap to other immune disorders [4]. In most cases fatigue improves with diet, but far from always. These patients present with a significant reduction in their health-related quality of life [2].
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