Abstract
Individuals suffering from acute infections typically experience systemic symptoms, including fever and musculoskeletal pain, as well as fatigue. Acute infections are also accompanied by increased slow wave sleep and stereotyped behavioural responses, including reduced motor activity, social withdrawal and anorexia. These manifestations are collectively termed the ‘acute sickness response’. The action of pro-inflammatory cytokines, such as interleukin (IL)-1 and IL-6 on the central nervous system mediate the key features of the response. In the great majority of cases, these constitutional symptoms, including fatigue, resolve in parallel with the fever. However, in a minority, a disabling fatigue statemay persist forweeks,months or (rarely) years. Many of the features of the acute sickness response remain evident in the prolonged fatigue state.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.