Abstract
Seven newborn chimpanzees injected at the time of birth with BSA and HoGG cleared the injected antigens at an exponential rate without evident antibody production following initial injection. When challenged with the same antigens, 4 of 7 injected with BSA and 4 of the 6 injected with HoGG were immune. Tolerance of BSA was seen in 3 of 7 chimpanzees and tolerance of HoGG in 2 of 6 chimpanzees. The initial response to BSA and HoGG of both the adult and newborn chimpanzees is an exponential decay of the antigen without a rapid phase of degradation. Re-injection of the antigens in an immune animal results in a rapid clearance and antibody production. These data suggest that newborn primates may react immunologically to foreign proteins either by antibody production or by immunological tolerance—the inhibition of antibody production to subsequent exposures to the same antigen. The dosage, maturity, and other factors which determine which outcome will follow a given exposure are not revealed by these studies. Therefore, it must be assumed that newborn primates, including humans, may be sensitized by foreign proteins administered parenterally or orally.
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