Abstract
14-Tetrahydrocannabinol was given to rats by i.v. injection, dissolved in polyethylene glycol or in rat serum, or endotracheal injection in cannabis smoke. Disapperance curves, measured over a period of 3 hr, differed according to the method of administration. Agarose gel electrophoresis of plasma showed that most of the 14C was bound to α- and β-lipoproteins. The greatest similarity of results was between injection in polyethylene glycol and smoke administration. Injection in serum gave slower disappearance from the plasma, a lower proportion of metabolites relative to THC, and different ratios of binding to albumin and α- and β-lipoproteins than the other two methods.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
